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Tag: toxic metabolites

Azathioprine and Allopurinol: How the Combination Prevents Toxic Metabolite Buildup

Azathioprine and Allopurinol: How the Combination Prevents Toxic Metabolite Buildup

LDAA therapy combines low-dose azathioprine with allopurinol to redirect toxic metabolite buildup in IBD patients. It’s effective for those with high TPMT activity and liver damage from standard therapy - but only with strict dosing and monitoring.

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